• Stroke / NDI scientists are among the worlds most active researchers using animal models of stroke. We offer expertise in the following models. click here for PDF • Sleep EEG / Potential therapies for insomnia, apnea, and other sleep disorders are typically evaluated in animal models with electrophysiological endpoints, in particular using electroencephalogram measures (EE).  NDI offers both rat and dog models for EEG measuring, pluse behavioral measures for canines. View or download (Rat Sleep EEG Methods) View or download (Dog Sleep Example) • Parkinson's Disease / There are three current techniques for producing in vivo models of Parkinson’s disease: unilateral lesioning with 6-hydroxydopamine (rats), systemic injection of 1-methyl 4-phenyltetrahydropyridine (MPTP)(mice and monkeys), and systemic injection of rotenone (rats). click here for PDF • Alzheimer's Disease/Mild Cognitive Impairment / Certain aged beagles develop major cognitive impairments as they age, and these are correlated with the extent of beta amyloid formation in frontal and entorhinal cortex. click here for PDF  (Alzheimer's disease) click here for PDF  (MCI) • In vivo microdialysis / In vivo microdialysis is a technique used to monitor the chemistry of extracellular space in living tissue. This chemical biosensor provides a preview of chemical changes in intact tissue - before those events are reflected as chemical changes in the blood. click here for PDF • Pain / NDI scientists are among the world’s most active researchers in the field of pain and analgesia. We offer expertise in the following models. click here for PDF • Phenotyping Mutant Mice click here for PDF • Multiple Sclerosis / The primate model is the marmoset, involving inoculation with whole human myelin. The principal endpoint is behavioral, with repeated measuring up to 3 or 4 months following disease induction. click here for PDF • Functional Target Validation (FTV) / Analyzing specific biological events relevant to your compound’s mechanism of intended action.  Multi-parametric activity can be observed simultaneously via High Throughput flow cytometry. click here for PDF  click here for PDF  • Obesity / Canines are becoming the preferred animal model for obesity research, because humans and canines have similar nutritive requirements, obesity-induced disorder (diabetes), consumption patterns (small number of large meals), and metabolic characteristics. click here for PDF • Anxiety, Depression and Psychosis /  NDI has a vast experience evaluating the efficacy of neurotransmitter related therapeutics in pre-clinical models. click here for PDF   click here for PDF