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Phenotyping / Screening


     NDI offers phenotyping of genetically altered mice, plus a new service, phenotyping/screening of compounds using zebrafish


Zebrafish phenotyping/screening


Why Zebrafish?


Zebrafish represent an ideal organism for neurophenotyping, high throughput screening, as well brain imaging studies, in order to speed up drug discovery and genetic screening.  Possessing high physiological and genetic homology to humans, zebrafish have become increasingly useful in studying a wide spectrum of human brain disorders, from brain cancer to epilepsy to complex affective disorders.  Baseline data on normal and pathological behaviors or spontaneous and induced brain tissue pathology have now become available in zebrafish, approaching the knowledge base of other well-studied laboratory animals such as rats.


For example studies (Click here)



Mouse phenotyping/screening

Mice that have been genetically altered, or treated with some agent, may be examined for the resulting phenotype.  The tests and assays used may be comprehensive, or selected to answer specific questions.


         Comprehensive exam

                 For an example of a comprehensive phenotyping exam (Click here)


         Selective phenotyping

                  For published examples (Click here1, Click here2)


         Selective testing of treated mice

                  For an example of selective testing of treated normal mice (Click here)



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