Preclinical contract research: animal models of neurological disorders:
Preclinical Amyotrophic lateral sclerosis models (ALS models)
NeuroDetective offers the standard pre-clinical model of amyotrophic lateral sclerosis (ALS) for efficacy testing of novel therapeutics, the SOD1 transgenic mouse (G93a mutation). The model is available from an in-house colony. The lab is fluent in both behavioral testing as well as study design issues related to achieving robust results with the standard survival measure. Complementary histopathological measurements are also used, i.e. motor neuron cell counting, somal measurements, and other immunohistochemical observations of glial activation or immune system responses.
For a detailed description of this model as used in NDI studies [Click here].