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Preclinical contract research: animal models of neurological disorders:

Preclinical Down's Syndrome / Fragile X Syndrome models

         Established mutant mouse models of both Fragile X Syndrome (Fmr-1-/-) and Down's Syndrome (Ts65Dn) are available, along with a unique model FRAXAD.  The latter is a cross between the well known Alzheimer's model (Tg2576) and Fmr-1-/- mice.  FRAXAD mice over-express human AbPP with the Swedish mutation in an Fmr-1-/- background.

         (For an example study [Click here])










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