Preclinical contract research: animal models of neurological disorders:
Preclinical Inflammation and Pain models
Acute pain
![](/userfiles/pain.jpg)
Chronic pain
- “Chung” model (neuropathic pain)
(For an example report ([Click here])
- “Brennan” model (post-surgical pain)
(For an example publication [Click here])
Inflammatory pain (acute/chronic[arthritic])
- Paw edema (induced by carrageenan [sub-cutaneous or intra-articular], histamine [intra-plantar], or lipopolysaccharide [intra-plantar])
(For an example publication [Click here])
(For an example publication [Click here])
![](/userfiles/pain2.jpg)
Inflammatory pain (chronic)
- Freund’s adjuvant injection (sub-cutaneous or intra-articular)
(For an example publication [Click here])
![](/userfiles/von frey.JPG)
Back pain
- Morphine-induced Straub tail (muscle relaxant model)
(For an example report [Click here])
Vascular pain
- EMG activity (flexor reflexes) following injection of test substance. Example data below:
![](/userfiles/Pain4.jpg)
Diabetic neuropathy
- Streptozotocin-induced neuropathy
(For an example report [Click here])
Chemotherapeutic pain
- Taxol or vincristine-induced
(For an example publications [Click here1; Click here2])
(For example data [Click here]
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![](/userfiles/emg1.JPG) ![](/userfiles/emg 2.JPG)
![For more information on our Pain models, click here.](/userfiles/PainButton.gif)
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