Non-Human Primate Studies
NDI has access to a large primate colony, that includes adult and aged rhesus. Most of these animals are pre-trained on various cognitive tasks. Others are pre-diabetic and diabetic. Available models range from cognitive impairment/enhancement, to schizophrenia, depression, autism, ADHD and diabetes. Dependent measures include PET imaging, EEG, radioligand binding, memory and executive function tasks, and home-cage quantitative observations.
Age-related memory deficits
Impairment in spatial delayed-response in aged rhesus (Click here for example study)
Memory enhancement in normal rhesus
Ketamine-induced cognitive impairment
Cognitive impairment in schizophrenia is modeled by treatment with ketamine.
Sites of drug action (FDG-PET)
Diabetic and pre-diabetic animals
Multiple measures are available for evaluating drug efficacy in pre-diabetic and diabetic monkeys, along with age-matched controls.
Insulin and glucose measurements
Biomarkers of inflammation
Measures of retinopathy and visual function
Cognitive functions, both hippocampus and frontal cortex related
FDG/PET imaging and radioligand binding
For a selected bibliography of all studies conducted at this facility, (Click here)