| Alzheimer's disease models |
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Rat
- Aged FBN strain (naturally occurring, gradual cognitive decline without concurrent motor decline)
- Amyloid injection-induced neurodegeneration in hippocampus
Mouse
- Several hAPP transgenic mouse models, plus an hTAU441 double-mutation mouse model
Dog (aged)
- Progressive age-related decline in memory, complex learning, activity, and social interaction tests
- Extent of cognitive decline correlated with amyloid plaque load and cortical atrophy
- Sleep-Wakefulness rhythms disrupted (EEG)
DMTS test in dogs (above)
In Vitro Assays
- Aß-induced neurotoxicity in mesencephalic and NT2N cells
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