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Preclinical contract research: animal models of neurological disorders:

Preclinical Alzheimer's models (AD models

Rat

Scopolamine-impaired adult rats, using standard water maze

(For an example contract study [Click here])

Naturally aged rats, using novel foraging/hoarding task

(For a published example of contract study [Click here])

 

Mouse

Audiogenic seizures in Tg2576 and FRA x AD mice

(For examples of this model [Click here1, Click here2])

 

Dog (aged beagle)

     Age-related declines in memory, activity, and social interaction correlated with cortical atrophy and plaque load, plus cerebral atrophy.  Age-related sleep disruptions also shown with EEG. 

(For further details [Click here])

 

 

                          

                                   DMTS test in dogs (above)

 

In vitro assays

     Abeta-induced neuron loss, with assays distinguishing test compounds that are either neuroprotective vs. neurotrophic

(For a redacted final report of contract study [Click here]).

 

For more information on our AD models, click here

  [Back to animal models list]

 


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