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Alzheimer's disease models
Rat
- Aged FBN strain (naturally occurring, gradual cognitive decline without concurrent motor decline)
- Amyloid injection-induced neurodegeneration in hippocampus

Mouse
- Tg 2576 (over-expressing human A-beta PP with Swedish mutation)
- FRAXAD (Tg 2576 with Fmr-1-/-, over-expressing hAbPP with Swedish mutation in an fmr-1-/- background)
- Double KO mice lacking both FMRP and APP

Dog (aged)
- Progressive age-related decline in memory, complex learning, activity, and social interaction tests
- Extent of cognitive decline correlated with amyloid plaque load and cortical atrophy
- Sleep-Wakefulness rhythms disrupted (EEG)
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DMTS test in dogs (above)
In Vitro Assays
- Anti-amyloid and anti-aggregation assays.
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