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Emesis model
| Ferrets are the animal model of choice for evaluating a compound’s anti-emetic properties, because of that animal’s similarities to humans in its neuroanatomy of the brain stem and stomach, and because of the ferret’s sensitivity to emesis-inducing agents. In this model an emesis-inducing agent such as the chemotherapeutic cisplatin, is administered under anesthesia. Following awakening, the numbers of episodes of retching and vomiting are counted. A test compound may be administered prior to, concurrent with, or immediately after the emesis-inducing agent. |
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