Preclinical contract research: animal models of neurological disorders:
Preclinical Down's Syndrome / Fragile X Syndrome models
Established mutant mouse models of both Fragile X Syndrome (Fmr-1-/-) and Down's Syndrome (Ts65Dn) are available, along with a unique model FRAXAD. The latter is a cross between the well known Alzheimer's model (Tg2576) and Fmr-1-/- mice. FRAXAD mice over-express human AbPP with the Swedish mutation in an Fmr-1-/- background.
(For an example study [Click here])