Primate model
Our primate model is the marmoset, inoculated with whole human myelin.  The principal endpoint is behavioral, with repeated measuring up to 3 or 4 months following disease induction, depending on the experimental design (prevention or treatment after onset of symptoms).  The principal investigator for this model is the person who developed it.  In addition to behavioral endpoints, there can also be imaging (MRI, for quantification of lesion volume), immunological (T cell reactivity, PBL's, splenocytes) and histopathological (inflammation and demyelination quantification) endpoints.  The model is considered to provide more information on the range of effects of a test compound compared to rodent models.

Rodent models
The following rat and mouse models of MS reflect varying aspects of the disease, including the two primary clinical forms of the disease, acute and relapsing/remitting. 

• Lewis rat acute experimental autoimmune encephalopathy (EAE), induced with spinal cord or myelin basic protein.

• Lewis rat adoptive EAE induced with myelin basic protein.

• Myelin oligodendrocyte glycoprotein (MOG)-induced EAE in the C57BL6 mouse.

• SJL mouse chronic EAE induced with proteolipid protein.

•  Biozzi mouse chronic relapsing EAE induced with lyophilised spinal cord.

• Experimental autoimmune uveoretinitis in the B10.RIII mouse.