Animal Models of Neurological Disorders: Pain and Inflammation

Pain and Inflammation

Models for efficacy testing

• Acute Inflammatory Models:
  Formalin
  Carrageenan (subcutaneous, intra-articular)
  
  • Chronic Inflammatory Models:
    Freund’s adjuvant (subcutaneous, intra-articular)
    
    • Acute Nociceptive Models:
      Tail-flick
      Hot-plate
      
      • Chronic Neuropathic Pain:
        Chung, Seltzer models, using measures of thermal, mechanical and chemical allodynia/hyperalgesia

• Vascular Pain:
  EMG recording of flexor reflexes

• Behavioral Analyses
  von Frey Threshold
  Allodynia / place avoidance

• Electrophysiological Analyses
  Single teased-fiber recording
  EMG recording