Models for efficacy testing

• Acute Inflammatory Models:
  Formalin
  Carrageenan (subcutaneous, intra-articular)

   

• Chronic Inflammatory Models:
  Freund’s adjuvant (subcutaneous, intra-articular)

   

• Acute Nociceptive Models:
  Tail-flick
  Hot-plate

   

• Chronic Neuropathic Pain:
  Chung, Seltzer models, using measures of thermal, mechanical and chemical allodynia/hyperalgesia

   

• Vascular Pain:
  EMG recording of flexor reflexes

• Behavioral Analyses
  von Frey Threshold
  Allodynia / place avoidance 

• Electrophysiological Analyses
  Single teased-fiber recording
  EMG recording