Models for testing efficacy of pain therapeutics

• Acute Pain Models

Hot-plate

Tail-flick

• Chronic Neuropathic Pain

Chung and Brennan models, using measures of thermal, mechanical and chemical allodynia/hyperalgesia

• Inflammatory Pain (Acute)

Paw edema, induced by carrageenan (sub-cutaneous or intra-articular), histamine (intra-plantar) or LPS (intra-plantar)

Formalin

• Inflammatory Pain (Chronic)

Freund's adjuvant (subcutaneous, intra-articular)

• Back Pain

Muscle relaxant model (Straub tail), with control tests for muscle weakness and overall sedation. 

• Diabetic Neuropathy
  

• Vascular Pain

EMG recording of flexor reflexes

• Behavioral Analyses

Mechanical allodynia (von Frey threshold, i.e. sensory measure)

PEAP (place escape / avoidance paradigm, i.e. affective [non-sensory] pain perception)

• Electrophysiological Analyses
  
  Single teased-fiber recording

EMG recording