|
Pain and Inflammation
|
Models for testing efficacy of pain therapeutics
Hot-plate Tail-flick
Chung and Brennan models, using measures of thermal, mechanical and chemical allodynia/hyperalgesia
- Inflammatory Pain (Acute)
Paw edema, induced by carrageenan (sub-cutaneous or intra-articular), histamine (intra-plantar) or LPS (intra-plantar) Formalin
- Inflammatory Pain (Chronic)
Freund's adjuvant (subcutaneous, intra-articular)
Muscle relaxant model (Straub tail), with control tests for muscle weakness and overall sedation.
STZ-induced allodynia
EMG recording of flexor reflexes
Mechanical allodynia (von Frey threshold, i.e. sensory measure) PEAP (place escape / avoidance paradigm, i.e. affective [non-sensory] pain perception)


- Electrophysiological Analyses
Single teased-fiber recording
EMG recording
|
 

[Back to animal models list]
|