Mouse

• The only model of progressive neuron loss in the SN (gradual lesion with MPTP)
• 3 behavioral tests: Rearing (wall-supported vs. free), Grid (foot-fault measure), and Treadmill (gait analysis)
• Loss of TH labeled cells in substantia nigra correlated with behavioral deficits

Rat

• 6-hydroxydopamine (6-OHDA) lesion, unilateral and bilateral 
• Akinesia test
• Forelimb asymmetry (cylinder) test 
• Amphetamine induced rotation
• Tremulous Jaw Movements (tremor measure) 

• MPTP lesion
• Parkinsonism activity scale
• Delayed Non-Match to Position test
• DPPH (determination of radical scavenging potential)
• Immunocytochemical determination of TH levels in substantia nigra and striatum
• Evaluation of dopamine release in striatum
• Evaluation of neuron survival in substantia nigra

In vitro assays