Parkinson's disease    

 


 

 

Mouse

  • The only model of progressive neuron loss in the SN (gradual lesion with MPTP)
  • 3 behavioral tests: Rearing (wall-supported vs. free), Grid (foot-fault measure), and Treadmill (gait analysis)
  • Loss of TH labeled cells in substantia nigra correlated with behavioral deficits

Rat

  • 6-hydroxydopamine (6-OHDA) lesion, unilateral and bilateral 
  • Akinesia test
  • Forelimb asymmetry (cylinder) test 
  • Amphetamine induced rotation
  • Tremulous Jaw Movements (tremor measure) 

Primate 
  • MPTP lesion
  • Parkinsonism activity scale
  • Delayed Non-Match to Position test
  • DPPH (determination of radical scavenging potential)
  • Immunocytochemical determination of TH levels in substantia nigra and striatum
  • Evaluation of dopamine release in striatum
  • Evaluation of neuron survival in substantia nigra

In vitro assays

For more information on our Parkinsons Disease models, click here.

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