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Preclinical contract research: animal models of neurological disorders:

Preclinical Parkinson's disease models (PD models)

For an in vitro assay of potential PD compounds, see the In Vitro Assays page.

         Rat (unilateral 6-OHDA lesion)

     Adult rats with this lesion exhibit several behavioral deficits, as well as show significant loss of both dopaminergic neurons in the substantia nigra and dopaminergic projections to the striatum on the lesioned side.  This model is known to be sensitive to test compounds that affect dopaminergic activity. 

(For an example study [Click here]).

         Mouse (MPTP lesion)

     This progressive-neuron-loss model of Parkinson’s disease uses repeated injections of low doses of the MPTP toxin, and multiple behavioral measures. 

For a description of this model [Click here] and for specific data on the effects of L-DOPA and nicotine in this model [Click here]

An acute high-dose of MPTP is also sometimes used with this model

For an example study [Click here]

 

         Mouse (induced dyskinesia)

     Current Parkinson’s disease treatments that target dopamine receptors produce dyskinesia with extended use.  To test therapeutics that may reduce these dyskinesias, different mouse models are used.  One model induces dyskinetic-like behaviors by prolonged treatment with L-DOPA

For a description of this model [Click here], while another induces oral tremors (tremulous jaw movements) using a combination of drugs or tetrabenazine (which depletes dopamine)

For an additional description of this model [Click here]

 

         Non-human primate (MPTP lesion)

     Monkeys treated with the MPTP toxin exhibit behaviors that parallel those seen in human Parkinson’s patients.  A specific behavioral scale is used in this model to test potential Parkinson’s disease therapeutics, intended for use as either a monotherapy or adjunct therapy. 

(For an example study [Click here]).

 

 

 

 

For more information on our Parkinsons Disease models, click here.

 [Back to animal models list]

 


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