A contract research network of neuroscientists

Animal Models of Neurological Disorders: Parkinson's disease

Since 2002, 72% of all NDI studies have come from repeat clients.
NeuroDetective International: Pre-clinical Contract Research - Parkinson's Disease

Parkinson's disease
 


Mouse

  • 1-methyl 4-phenyltetrahydropyridine (MPTP) lesion
  • Skilled reaching test
  • Supported vs. unsupported rearing
  • Tail-hang test
  • Open Field activity

Rat

      • 6-hydroxydopamine (6-OHDA) lesion, unilateral and bilateral
      • Skilled reaching test
      • Akinesia test
      • Forelimb asymmetry (cylinder) test
      • Staircase test
      • Amphetamine induced rotation
      • Vacuous chewing (dyskinesia measure)
      • Rotenone lesion (low-dose, high-dose)

Primate

                • MPTP lesion
                • Parkinsonism activity scale
                • Delayed Non-Match to Position test
                • DPPH (determination of radical scavenging potential)
                • Immunocytochemical determination of TH levels in substantia nigra and striatum
                • Evaluation of dopamine release in striatum
                • Evaluation of neuron survival in substantia nigra

In vitro assays

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