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Schizophrenia is diagnosed on the basis of positive symptoms (e.g., auditory hallucinations, paranoia, aimless or purposeless behavior) or negative symptoms (e.g., emotional affect, social withdrawal, reduced movement).Accordingly, models of schizophrenia are divided into three general categories 1) general screening, 2) targeted positive symptom models, and 3) targeted negative symptom models.The following models in these categories are offered by NDI:
General Screening Models
NDMA antagonist-induced locomotor activity
Positive Symptom Models
Conditioned Avoidance Response
Inhibition of amphetamine-induced activity
Negative Symptom Models
Pre-Pulse Inhibition (PPI) of acoustic startle
PCP Social Interaction
There are often adverse effects of anti-psychotics.A model that assesses these potential adverse side-effects (catalepsy) is also offered.