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Preclinical contract research: animal models of neurological disorders:

Preclinical Stroke models

     NDI university scientists are among the world’s most active researchers in the stroke field, employing several clinically appropriate animal models that emphasize behavioral recovery.  These models fall into two general categories:  ischemic stroke models and hemorrhagic stroke models.  The most frequently used ischemic model is MCAO (middle cerebral artery occlusion, both acute and chronic).  Hemorrhagic models include ICH (intra-cerebral hemorrhage) and SAH (sub-arachnoid hemorrhage).


Dependent measures

     A key aspect of all these models is the use of multiple behavioral tests to assay functional recovery.  This is because a potential therapeutic may either restore lost functions, or speed up the recovery of functions that the stroke has not completely abolished.

     Another critical aspect is the use of several histological and immunohistological stains (e.g., Golgi-Cox, NeuN) to examine the effect of a potential therapeutic not only on the infarct or lesion area, but on the surrounding (penumbra) and anatomically connected areas.  Telemetry may also be used to measure brain and body temperature, intracranial pressure, blood glucose, and blood gases.



     For examples of contract stroke studies from NDI laboratories                                   [Click here1, Click here2]



For more information on our Stroke models, click here.

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